activator protein 1 การใช้

PPAR? increases activity of activator protein 1 ( AP-1 ) and NF-?B, thereby leading to the recruitment of inflammatory T cells.
The promoter of the human MMP7 contains a TATA box, an activator protein 1 ( AP-1 ) site, and two inverted polymavirus enhancer A-binding proteins 2 ( PEA-3 ).
Transcriptions factors have different binding sites for its development, some examples are : GATA, activator protein 1 and 2 ( AP-1 and AP-2 ), and numerous potential Octamer-1 binding sites.
The encoded protein is an integral subunit of the NCOR1-HDAC3 ( nuclear receptor corepressor 1-histone deacetylase 3 ) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 ( activator protein 1 ) function.
As shown by some experiments reviewed by Del Razo ( 2001 ), ROS induced by low levels of inorganic arsenic increase the transcription and the activity of the activator protein 1 ( AP-1 ) and the nuclear factor-?B ( NF-?B ) ( maybe enhanced by elevated MAPK levels ), which results in c-fos / c-jun activation, over-secretion of pro-inflammatory and growth promoting cytokines stimulating cell proliferation.